A One Pot, Solvent Free and Catalyst Free Synthesis of Substituted 2-Amino-5-Aryl-1,3,4-Oxadiazoles under Microwave Irradiation

Author(s): Kinjal D. Patel, Rajesh H. Vekariya, Hitesh D. Patel

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016

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Graphical Abstract:


A convenient one-pot, multi-component and solvent free procedure for the preparation of substituted 2-amino-5-aryl-1,3,4-oxadiazoles has been achieved. The method is a significant improvement over previously reported synthesis. Reaction of acid chlorides with hydrazine hydrate and isothiocynates under microwave-irradiation (MWI) afforded the corresponding 1,3,4-oxadiazole derivatives in high yields with high purity. All synthesized compounds were characterized by FT-IR, proton and carbon NMR, mass spectroscopy and elemental analysis. A possible mechanism is proposed for the cyclodesulfurization based on the results of this study.

Keywords: Catalyst free one pot reaction, microwave irradiation, multi component reaction, oxadiazole, solvent.

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Article Details

Year: 2016
Published on: 30 October, 2015
Page: [24 - 30]
Pages: 7
DOI: 10.2174/2213335602666150324233632

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PDF: 129