Hepatocellular carcinoma is a leading unnatural death worldwide, and it causes second most
common cancer related death. Hepatocellular carcinoma development is distinct from other types of
cancer, which is usually based on hepatic cirrhosis resulted from various etiologies including viral
hepatitis, non-alcoholic liver diseases and alcohol abuse. MicroRNAs (miRNAs) are a group of small,
non-coding sequences with approximate 20~ bp in length, which post-transcriptionally regulates target
genes to control multiple biological activities. Recent studies have indicated that miRNAs contribute
to hepatocellular carcinoma, indicating that targeting miRNAs might be a novel therapeutic strategy for the management
of hepatocellular carcinoma. In this review, we summarized recent advances in the role of miRNAs in hepatocellular
carcinoma, and also discussed the potential therapeutic and prognostic values of miRNAs in hepatocellular carcinoma.
Keywords: Apoptosis, hepatocellular carcinoma, meta, MicroRNA, proliferation.
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