The present outbreak associated with Ebola disease in Western countries of the African continent
which is believed to be one of the massive eruptions caused by the Ebola viral infections. In the
present scenario ebola has been transmitted to the European and American regions through the travelers
from wide spread countries like Guinea, Liberia, Sierra Leone and Nigeria. The viral disease is
spreading through the contact in any form by the infected persons or patients and creating huge risks to
the mortals. The symptoms related to ebola virus are often highly pathogenic; about 70-80% of death
cases are reported due to critical hemorrhagic fever. Early in infection, ebola virus infects macrophages and endothelial
cells. It mainly produces a Viral Protein 24 (eVP24) which prevents interferon-based signals which are important for destruction
of viruses. How ebola virus manipulates the function of the immune system is still unclear. Due to lack of this
knowledge, no approved treatment is available. In this review, we have tried to compile the epidemiology, pathogenesis
and treatment of ebola virus infection. The promising ligands against ebola virus have been also discussed which will be
helpful for researchers to design drugs for the treatment of ebola virus disease.
Keywords: Ebola virus, pathogenesis, treatment, vaccines, vp24 inhibitors.
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