With the alarming resistance to currently used antibiotics, there is a serious worldwide
threat to public health. Therefore, there is an urgent need to search for new antibiotics or new cellular
targets which are essential for survival of the pathogens. However, during the past 50 years, only two
new classes of antibiotics (oxazolidinone and lipopeptides) have reached the clinic. This suggests that
the success rate in discovering new/novel antibiotics using conventional approaches is limited and that
we must reconsider our antibiotic discovery approaches. While many new strategies are being pursued
lately, this review primarily focuses only on a few of these novel/new approaches for antibiotic discovery.
These include structure-based drug design (SBDD), the genomic approach, anti-virulence strategy, targeting nonmultiplying
bacteria and the use of bacteriophages. In general, recent advancements in nuclear magnetic resonance, Xcrystallography,
and genomic evolution have significant impact on antibacterial drug research. This review therefore aims
to discuss recent strategies in searching new antibacterial agents making use of these technical novelties, their advantages,
disadvantages and limitations.
Keywords: Acylated homoserine lactone, antibiotics, antibiotic discovery, antivirulence strategy, autoinducers, bacteriophages,
genomic approach, non-multiplying bacteria, phage therapy, quorum sensing, resistance, screening strategies, structure-based
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