Drug of abuse or illicit drugs have become a serious health issue and global evils during the last few
decades. Their detection is a significant area of research, for preventing illegal traffic and toxic effects on human
health and society. Numerous analytical methods, based on diverse principles, have been developed for the detection
of drugs of abuse. The core intention of present review is to pioneer the reader with the varieties of drugs of
abuses (availability, formation, and use and ill-use) as well detection techniques developed and employed in the
past few years. The study includes a comparative review of analytical detection techniques. Effectiveness of
chemical sensors over other analytical techniques is particularly emphasized.