Repetitive Transcranial Magnetic Stimulation to Treat Substance Use Disorders and Compulsive Behavior

Author(s): Maria I.B. Protasio, Joao P.L. da Silva, Oscar Arias-Carrion, Antonio E. Nardi, Sergio Machado, Marcelo S. Cruz

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 14 , Issue 3 , 2015

Become EABM
Become Reviewer
Call for Editor


Compulsions, like pathological gambling, binge-eating disorder, alcohol, tobacco or cocaine abuse and compulsive shopping have similar neurophysiological processing. This study aimed to examine the efficacy of repetitive transcranial magnetic stimulation (rTMS) in improving patient control over compulsive behavior. The rTMS modulatory role in cortical mesolimbic pathways possibly implies improvement of the inhibitory control system and compulsive consumption drive. Thus, craving reduction would be a component for control achievement. Within this context, 17 studies were found. Most studies applied rTMS over the left dorsolateral prefrontal cortex. Craving reduction was observed in 10 studies and was associated with improved control of compulsion in two of them. In one study reduction in consumption was found without reduction in craving. In addition, improvement in decision making was found in one study.

Keywords: Alcohol, binge eating, cocaine, compulsion, gambling, repetitive transcranial magnetic stimulation, tobacco.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2015
Published on: 15 April, 2015
Page: [331 - 340]
Pages: 10
DOI: 10.2174/1871527314666150318114043
Price: $65

Article Metrics

PDF: 47