The Applications of Targeting Anti-Cancer Agents in Cancer Therapeutics

Author(s): Guang-Chun Sun, X u Yang, Yan Yu, Dai-Wei Zhao

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 15 , Issue 7 , 2015

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Graphical Abstract:


Anti-cancer targeting drugs appear to be a new and powerful "weapon" for cancer therapies. These targeting drugs are directed against specific molecules that are over-expressed or where certain unique factors are aberrantly expressed either in cancer cells or in diseased cell sites. Compared with traditional chemotherapeutic drugs, these targeting drugs have the advantages of high specificity, efficacy and less side effects. Target therapy is a breakthrough and revolutionary advance in the field of cancer therapy. Tumor angiogenesis plays a key role in tumor growth and metastasis and the mutation of tyrosine kinases is also strongly associated with cancer progression. Thus, in this review, we will discuss the advances in the development of targeting anti-cancer drugs by narrowing it down to small molecule tyrosine kinase inhibitors, monoclonal antibodies against epidermal growth factor receptors belonging to the ErbB family of receptor tyrosine kinases and angiogenic inhibitors. It will also address concerns for drug resistance and adverse events.

Keywords: Angiogenesis, cancer, combination therapy, signaling pathway, target therapy, tyrosine kinase.

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Article Details

Year: 2015
Page: [869 - 880]
Pages: 12
DOI: 10.2174/1871520615666150318101845
Price: $65

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