Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and
certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal
models of SSc have been developed and are available for research studies. The purpose of this review is to summarize
the various animal models of systemic sclerosis and describe the various contributions of these models in
terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this
Keywords: Systemic sclerosis, fibrosis, vasculopathy, auto-immunity, mice, transgenic, knock-out, topoisomerase-1.
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