Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such
as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides
to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium-
177 (177Lu) has been successfully used in peptide radionuclide therapy. Recently, 177Lu-AuNPs conjugated
to different peptides have been proposed as a new class of theranostic radiopharmaceuticals.
These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems
and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization,
molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with 177Lu
and conjugated to RGD (-Arg-Gly-Asp-), Lys3-Bombesin and Tat(49-57) peptides.
Keywords: Bombesin, cancer thermotherapy, gold nanoparticles, gold nanoparticles-peptides, lutetium-177, RGD, targeted
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