Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Author(s): Prasanna A. Datar, Saleel A. Limaye

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 14 , Issue 1 , 2015

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Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.

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Article Details

Year: 2015
Page: [35 - 46]
Pages: 12
DOI: 10.2174/1871523014666150312164625

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PDF: 55