Given the paucity of effective therapies and the increasing prevalence of osteoarthritis
(OA) with ageing and overweight populations, new therapies for this painful, life-impairing
condition are desperately needed, for both symptom relief and structural modification. With a
growing understanding that OA involves multiple tissue pathologies including inflammation,
many more therapeutic targets have been identified. This review will provide a current overview
on the role of biologics in OA, including anti-tumour necrosis factor agents, growth factors and
Keywords: Osteoarthritis, tumour necrosis factor, interleukin-1, growth factors, calcitonin gene related peptide, biologics.
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