Staphylococcus aureus is a fastidious pathogen of global concern. S. aureus can not
only cause a wide range of serious infections, but can also colonize healthy individuals. Nosocomial-
associated S. aureus infection is a major concern for healthcare facilities. Recent increases
in antibiotic resistance and community-acquired infection highlight the need for improved
understanding for prevention and treatment of this pathogen. This minireview addresses
the current state of S. aureus prevalence, correlates of immunity, and vaccine development.
Keywords: Staphylococcus, vaccine, animal models, antibiotic resistance, biomarker.
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