The aim of this study was to examine the anticancer activities and phytochemical profiles of
Dicranum scoparium against HeLa cell lines. The bio-guided fractionation studies of dichloromethane
extract have high antiproliferative activities. Fractions 7, 9, 19, 20 are rich source of unsaturated fatty
acids, and- in the case of Fr-19 may improve the antiproliferative activities as well as increase the
unsaturated fatty acid content. The effect of proliferative activities in hexane extract can be attributed
to the saturated fatty acid composition of D. scoparium. The Fr-9 exhibited strong antiproliferative activity at
concentrations of 100 and 50 μg mL-1 compared to 5-FU. The fractions of 7, 9, 19 and 20 from dichloromethane extracts
exhibited antiproliferative activities at a concentration of 100 μg mL-1. The HPLC-TOF/MS studies gave nine compounds
from the most active fraction of dichloromethane at concentrations of 250 and 100 μg mL-1. The lower activities were
obtained from the fractions including steroid derivatives.
Keywords: Anticancer, bryophyte, separations, volatile contents.
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