This study investigated whether a low estimated glomerular filtration rate (eGFR) leads to a higher risk of
stroke recurrence and a poor prognosis in hemorrhagic stroke patients. A total of 2000 stroke patients were recruited
during 2000-2001 and prospectively followed up for a median of 4.5 years. The independent association of a low eGFR
with stroke recurrence and poor prognosis was evaluated using Kaplan–Meier analysis and Cox regression models.
Among the hemorrhagic stroke patients, the incidence rate of a low eGFR for the compound endpoints (stroke recurrence,
myocardial infarction, and all-cause mortality) was greater than that of a normal eGFR (P=0.012). A similar result was
observed for the incidence rate of recurrence and death caused by cardiovascular disease or stroke (Csdeath) (P=0.013,
and P=0.001, respectively). After adjustment for age, sex, and other cardiovascular risk factors, a low eGFR was
associated with a 2.93-fold increased risk of the compound endpoints (P=0.001, RR=2.93, 95% CI=1.58-5.43), 3.06-fold
increased risk of recurrent stroke (P=0.003, RR=3.06, 95% CI=1.46-6.40), and 3.57-fold increased risk of Csdeath
(P=0.005, RR=3.57, 95% CI=1.46-8.70) among hemorrhagic stroke patients. Among the hemorrhagic stroke patients, a
low eGFR was a strong predictor of stroke recurrence and a poor prognosis.