Progresses of Somatostatin Quantification for Clinical Practice

Author(s): Wenjuan Yang, Jing Li, Jinhang Gao, Zhiyin Huang, Chengwei Tang

Journal Name: Current Pharmaceutical Analysis

Volume 11 , Issue 3 , 2015


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Abstract:

Somatostatin (SST), a cyclic polypeptide, exerts a wide range of biological effects. As a result, decreased SST in plasma or tissues usually plays an important role in pathogenesis of various disorders. Exogenous supplement of SST or its analogues has been applied as an effective medical intervention in many diseases. The quantification of SST in plasma or tissues may provide a more rational application of SST in clinical practice. Currently, several methods for SST quantification have been established. The advantages and drawbacks of these methods are reviewed for clinical selection or further study. Moreover, necessary collection, extraction and preservation of samples for SST quantification are also recommended. Surface plasmon resonance (SPR) is a label-free optical detection technique for measuring biomolecular interactions in real-time. Among the several quantitative methods, an SPR-based immunoassay is suggested as a potential method for real-time SST quantification for clinical practice.

Keywords: Enzyme-linked immunosorbent assay, high-performance liquid chromatography, octreotide, surface plasmon resonance, radioimmunoassay, somatostatin.

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2015
Published on: 05 May, 2015
Page: [164 - 172]
Pages: 9
DOI: 10.2174/1573412911666150305000000
Price: $65

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