Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Safety of Inositol and Inositol Phosphates

Pp. 275-282 (8)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Owing to the various health benefits of inositol and inositol phosphates, especially InsP6, and their availability as nutritional supplement for human consumption, it is imperative that their safety be addressed. The safety of myo-inositol has not been an issue, however, there have been lingering doubts in some quarters about the safety of InsP6. There had been some unsubstantiated concerns in the past regarding the intake of foods high in InsP6 that might reduce mineral bioavailability; recent studies using extracted salts of InsP6 have refuted those. Both inositol and InsP6 have been listed as “generally recognized as safe” by the US FDA. There should therefore be no concern for their consumption as appropriate.

Keywords:

Bioavailability, cooking methods, culture media, GRAS, infant formula, low phytate mutant, lpa, Mediterranean diet.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.