Mechanisms of Biological Actions of Inositol and InsP6 III: Epigenetics, Telomerase, Angiogenesis
Pp. 252-260 (9)
A.K.M. Shamsuddin and Guang-Yu Yang
Epigenetic changes such as DNA methylation, histone modifications etc., are
also important in cancer formation. InsP6 reverses the carcinogen-induced epigenetic
changes in at least two different carcinogen-induced lung cancer models. InsP6 has also
been found to repress telomerase activity in prostate and brain cancers. For cancer to
metastasize, the cells need access to blood vessels to disseminate. Formation of new
blood vessels - angiogenesis facilitates the process. InsP6 has been demonstrated to
inhibit angiogenesis both in vitro and in vivo. This is mediated by suppression of proangiogenic
factors such as vascular endothelial growth factor (VEGF).
Angiopoietin, calreticulin, FGF, histone modification,
hypermethylation, iNOS, matrix metalloproteinase, microRNA, microvessel
density, MMP, PDGF, TERT, telomerase reverse transcriptase, TRAMP,
The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.