Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Mechanisms of Biological Actions of Inositol and InsP6 III: Epigenetics, Telomerase, Angiogenesis

Pp. 252-260 (9)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Epigenetic changes such as DNA methylation, histone modifications etc., are also important in cancer formation. InsP6 reverses the carcinogen-induced epigenetic changes in at least two different carcinogen-induced lung cancer models. InsP6 has also been found to repress telomerase activity in prostate and brain cancers. For cancer to metastasize, the cells need access to blood vessels to disseminate. Formation of new blood vessels - angiogenesis facilitates the process. InsP6 has been demonstrated to inhibit angiogenesis both in vitro and in vivo. This is mediated by suppression of proangiogenic factors such as vascular endothelial growth factor (VEGF).

Keywords:

Angiopoietin, calreticulin, FGF, histone modification, hypermethylation, iNOS, matrix metalloproteinase, microRNA, microvessel density, MMP, PDGF, TERT, telomerase reverse transcriptase, TRAMP, vasostatin, VEGF.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.