Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Mechanisms of Biological Actions of Inositol and InsP6 II: DNA Damage Repair

Pp. 243-251 (9)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

DNA damage is one of the earliest changes in cancer formation. Within the cell and the nucleus, inositol and its phosphates are found wherein they are involved in DNA damage repair machinery, chromatin remodeling, RNA editing and mRNA transport.

Keywords:

Chromatin remodeling, mRNA transport, nuclear pore, NHEJ, NPC, RNA editing, RNA interference.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.