Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Mechanisms of Biological Actions of Inositol and InsP6 I: Cell Survival, Proliferation and Differentiation

Pp. 227-242 (16)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

A fundamental defect in cancer cells is the abnormal and uncontrolled cell proliferation. Along with that, there is de-differentiation to an immature or primitive phenotype. InsP6 and inositol normalize the abnormal cell proliferation rate and induce increased differentiation so that the cancer cells begin to look and behave akin to normal cells. Examples of these are shown in colon cancer, erythroleukemia and mammary cancer, and rhabdomyosarcoma cells. In colon cancer cells that produce the cancer marker ß-D-Galactose-[1→3]-N-acetyl-D-galactosamine (Gal-GalNAc), InsP6 inhibits the expression of the marker in the intracellular mucus without suppressing the production of mucus, a normal function of colon epithelial cells.

Keywords:

Aberrant crypt, ACF, actin, anoikis, apoptosis, erythroleukemia, HeLa cells, HL-60 cells, lactalbumin, mucin, PCNA, rhabdomyosarcoma, tumor marker.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.