Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Roles of Inositol & Inositol Phosphates in Immunity, Infection and Inflammation

Pp. 216-226 (11)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

InsP6 with or without inositol enhances NK cell activity and stimulates polymorphonuclear cell priming function and the macrophages to produce cytokines. InsP6 can inhibit human immunodeficiency virus (HIV) replication; both InsP5 and InsP6 are critical in HIV particle assembly. InsP6 plays significant roles in mucosal protection in the gastrointestinal tract, and inflammation.

Keywords:

Asbestosis, gastric ulcer, granzymes, HIV, macrophage, natural killer, NK cells, perforin, polymorphonuclear cells.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.