Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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The Roles of Inositol and its Phosphates in Neuropsychiatric Disorders

Pp. 164-175 (12)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

There are experimental data showing beneficial actions of inositol and inositol hexaphosphate (InsP6) in Alzheimer’s disease and Parkinson’s disease. The different stereoisomers of inositol, myo-, epi-, scyllo- and chiro-inositol have shown efficacy in Alzheimer’s disease. The antioxidant and cation chelating properties of InsP6 are considered to be some of the mechanisms; those of myo-inositol are not clear. Insofar as psychiatric diseases, lithium salts have been in use since the 1950s for bipolar disorder. While on one hand there is reduction of myo-inositol by lithium, myo-inositol on the other hand has been found useful in psychiatric disorders, and at least in one study of bipolar disorder. Thus, further studies of myo-inositol, and InsP6 in the treatment of bipolar disorder are warranted. A clinical trial of InsP6 in bipolar disorder is underway.

Keywords:

Alzheimer’s disease, BACE 1, bipolar disorder, CGI-S, HAM-D, Levodopa, lithium, MADRS, OCD, panic disorder, Parkinson’s disease, Y-BOCS.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.