Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Mineralization Disorders

Pp. 149-163 (15)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Owing to the ability to chelate calcium, InsP6 has been studied as a preventive and therapeutic agent for abnormal calcification in various tissues such as blood vessels in atherosclerosis and skin in calcinosis cutis; kidney and salivary gland stones; prevention of dental caries and bone loss as in osteoporosis, etc. The results are very promising for wide-range practical application of InsP6 especially against the serious debilitating problem of osteoporosis amongst the seniors, globally.

Keywords:

Calcinosis cutis, caries, crystallization inhibitor, dystrophic calcification, fluoride, hydroxyapatite, kidney stone, metastatic calcification, osteoblast, osteoclast, pyrophosphate, sialolithiasis, titratable acidity, tooth decay.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.