Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Atherosclerosis and Cardiovascular Diseases

Pp. 139-148 (10)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Atherosclerotic cardiovascular disease results in serious life threatening conditions such as heart attack, stroke etc. Hypercholesterolemia is a risk factor; studies show that InsP6 can lower serum cholesterol level. Oxidative damage seems to play an important role in the pathogenesis of atherosclerosis as well as in heart attack. Studies show that InsP6 by virtue of its antioxidant function can prevent or ameliorate some of the deleterious sequel.

Keywords:

Atheroma, cholesterol, HDL, heart attack, hypercholesterolemia, LDL, myocardial infarction, reperfusion injury, ROS, stroke, thrombosis.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.