Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Disorders of Metabolism

Pp. 128-138 (11)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

InsP6 and inositol independently may help in diabetes; InsP6 by stimulating insulin secretion by the pancreatic β cells. Both inositol and InsP6 can prevent oxidative damages to the cells and tissues inflicted through advanced glycosylated end products by acting as antioxidants. InsP6 and inositol could replenish the low intracellular inositol since they do not need insulin to gain entry into the cell. They also have positive effect on the abnormalities of fat metabolism such as hypercholesterolemia and fatty liver.

Keywords:

Advanced glycosylated end-products, AGE, cirrhosis, embryopathy, endothelial dysfunction, fatty liver, gestational diabetes, glycosylated hemoglobin, hypercholesterolemia, xenobiotics.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.