Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Radiation Protection by Inositol & its Phosphates

Pp. 117-127 (11)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Radiation is a common environmental carcinogen; humans are most often exposed to it from ultraviolet (UV) rays from the sun during sunbathing. There are other forms of radiation that we are exposed to owing to occupational or medical necessity. Radiation damage to health can be acute or chronic, the latter culminating in cancer. Uranium used in nuclear technology is also an important source of radiation. InsP6 has shown to be a much more efficient chelator of uranium than the currently available therapy for uranium poisoning as in nuclear disasters. Inositol and InsP6 have been proven to be protective against ultraviolet (UV) light-induced acute and chronic effects, including skin cancer.

Keywords:

Alopecia, AP-1, apoptosis, NF-kB, radiation damage, skin cancer, Ultraviolet, uranium, UVB.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.