Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Clinical Studies of Human Cancer Treatment

Pp. 107-116 (10)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Despite compelling experimental evidence of the efficacy of InsP6 + inositol as an anticancer cocktail, there has been very limited enthusiasm for clinical studies of cancer prevention and/or therapy. Notwithstanding this lack of interest, results from the handful of clinical studies are extremely encouraging. Myo-inositol with or without InsP6 has shown to be effective in preventing precancerous lesions of lung cancer. Experimentally, InsP6 acts synergistically with standard chemotherapeutic drugs such as doxorubicin and tamoxifen; emerging clinical data support that. InsP6 + inositol available as dietary supplement has been reported to cause abrogation of breast, lung and colorectal cancers, with or without standard therapies; reduce chemotherapyinduced negative side-effects and provide a better quality of life.

Keywords:

Alopecia, beta-glucan, breast cancer, chemotherapy, colon cancer, lung cancer, polychemotherapy, quality of life, radiotherapy.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.