Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Experimental Cancer Regression by InsP6 & Inositol

Pp. 83-106 (24)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Towards the eventual goal of translating the cancer inhibitory effect of inositol & InsP6 seen in experimental animals in vivo to cancer prevention and therapy in humans, studies of human cancer cells lines were performed in vitro; and human cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A consistent and reproducible broad-spectrum anticancer action of InsP6 ± inositol was observed in various models; in human breast cancer model InsP6 showed synergism with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression of preexisting cancer was seen in hepatoma model. InsP6 ± inositol also inhibited various steps in cancer metastasis, inositol potentiated the action. These findings are compelling reasons for application of InsP6+inositol for human cancer control.

Keywords:

Adriamycin, CEA, chemotherapeutic agent, collagen, fibronectin, haptotactic migration, HepG2, hepatoma, hepatocellular carcinoma, laminin, MCF-7, MDA MB 231, metastasis, MMP, nude mice, Tamoxifen, TRAMP, synergism, xenotransplantation.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.