Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Experimental Cancer Prevention by InsP6 & Inositol

Pp. 67-82 (16)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Myo-inositol and InsP6 have independent anticancer action against divergent types of malignancies in a consistent and reproducible manner. The anti-cancer action is dose-dependent and inositol acts synergistically with InsP6 to enhance the anticancer action of the latter. Since inositol and InsP6 are common constituents of cereals and legumes, comparative study of high bran diet with equivalent amount of InsP6 showed that while the ‘high fiber’ diet failed to reduce the incidence of experimental cancer, InsP6 alone at equivalent dose significantly inhibited mammary cancer formation. Combined with the other studies, these data strongly suggest that supplementation with pure inositol + InsP6 may be better than gobbling a large amount of fiber.

Keywords:

AOM, CD, colitis, Crohn’s disease, DMBA, DMH, pre-initiation, post-initiation, tumor promoter, UC, ulcerative colitis.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.