Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Pharmacokinetics of InsP6

Pp. 57-66 (10)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Studies have shown that InsP6 is rapidly absorbed from the gastrointestinal tract, distributed through the plasma to various organs including the brain, and excreted from the lungs via exhaled air and through the kidneys via urine as inositol, InsP1-5 and InsP6. That it is distributed in brain indicates that it crosses the blood-brain barrier. Also challenging the dogma is that at least in mice, InsP6 is distributed in the red blood cells as well. InsP6 is rapidly taken up by malignant cells wherein it is precipitously dephosphorylated to various lower phosphates; depending on the cell types, the proportion of these lower inositol phosphates varies. Inositol is also rapidly absorbed by humans.

Keywords:

Blood-brain barrier, GC-MS, internalization, red blood cells, visualization.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.