Signaling Role of Inositol and its Phosphates
Pp. 24-49 (26)
A.K.M. Shamsuddin and Guang-Yu Yang
Inositol and its phosphates are integral parts of cellular signaling. InsP6 is
plentiful in organisms as diverse as yeast, actinobacteria, mammals and plants. In the
plant kingdom, InsP6 accumulates during seed development; at the time of germination
it is broken down into lower inositol phosphates and micronutrients to maintain
seedling. InsP6 is the most abundant of intracellular inositol phosphates in eukaryotes.
In mammals InsP6 maintains homeostasis, stores phosphate and acts as strong antioxidant
and neurotransmitter. InsP6 and other inositol phosphates including the
pyrophosphates, play critical roles in cellular pathways involved in signal transduction,
control of cell proliferation and differentiation, RNA export, DNA repair, energy
transduction, ATP regeneration etc. By enabling communication between nucleus,
cytoplasm, and the outside environment, InsP6 and the other inositol phosphates play a
crucial role in many aspects of cell biology.
Apoptosis, ATP, auxin, cell proliferation, clathrin, coated pits,
differentiation, DNA repair, eukaryote, exocytosis, FGF, MAPK, nuclear pore,
PKC, prokaryote, RNA export, signal transduction, syndecan, zinc finger.
The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.