Inositol & its Phosphates: Basic Science to Practical Applications

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functions such as signal transduction, DNA damage repair ion transport ...
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Inositol Compounds: Natural Sources and Chemistry

Pp. 3-15 (13)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Considerable evidence has accumulated indicating a significant role of dietary inositol and its phosphates, and phospholipid derivatives in human health. In a typical American diet, the amount of myo-inositol per 2500 kcal diet is approximately 900 mg, and most of the inositol compounds are phospholipid derivatives. Virtually all of the ingested myo-inositol (99.8%) is absorbed from the human gastrointestinal tract. In general a normal circulating fasting plasma myo-inositol concentration is approximately 0.03 mM and this material turns over with a half-life of 22 minutes. Contrary to the misconception held by some, inositol hexaphosphate (InsP6) likewise is also rapidly absorbed (79 ± 10%) and distributed widely throughout the body. While there are interspecies variations, in general they all point to rather rapid absorption. Following an InsP6-poor diet, the basal plasma value in humans is 0.07 ± 0.01 mg.L-1 that rises to 0.26 ± 0.03 mg.L-1 after ingestion of InsP6-normal diet.

Keywords:

Inositol hexaphosphate, inositol pyrophosphates, InsP6, isomers, phytate, phytic acid, polyphosphate.

Affiliation:

The University of Maryland School of Medicine 10 S. Pine Street, MSTF-700 Baltimore, MD 21201-1116 USA., Northwestern University Feinberg School of Medicine 303 E Chicago Ave, Ward 4-115 Chicago, IL 60611 USA.