Inositol Compounds: Natural Sources and Chemistry
Pp. 3-15 (13)
A.K.M. Shamsuddin and Guang-Yu Yang
Considerable evidence has accumulated indicating a significant role of
dietary inositol and its phosphates, and phospholipid derivatives in human health. In a
typical American diet, the amount of myo-inositol per 2500 kcal diet is approximately
900 mg, and most of the inositol compounds are phospholipid derivatives. Virtually all
of the ingested myo-inositol (99.8%) is absorbed from the human gastrointestinal tract.
In general a normal circulating fasting plasma myo-inositol concentration is
approximately 0.03 mM and this material turns over with a half-life of 22 minutes.
Contrary to the misconception held by some, inositol hexaphosphate (InsP6) likewise is
also rapidly absorbed (79 ± 10%) and distributed widely throughout the body. While
there are interspecies variations, in general they all point to rather rapid absorption.
Following an InsP6-poor diet, the basal plasma value in humans is 0.07 ± 0.01 mg.L-1
that rises to 0.26 ± 0.03 mg.L-1 after ingestion of InsP6-normal diet.
Inositol hexaphosphate, inositol pyrophosphates, InsP6, isomers,
phytate, phytic acid, polyphosphate.
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