Motility Disorders, Functional Gastrointestinal Disorders, Inflammatory Bowel Disease and Cardiac Rhythm Disturbances - Is there a Link? Review of Literature

Author(s): Michal Zorniak, Marek Waluga, Marek Hartleb

Journal Name: Current Drug Targets

Volume 16 , Issue 3 , 2015

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Gastrointestinal disorders are frequently accompanied by symptoms exceeding gastrointestinal tract. This is at least partially connected with the involvement of autonomic nervous system in pathophysiology of diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) or spectrum of motility disorders. In light of the above, involvement of cardiovascular system in natural history of gastrointestinal disorders seems to be of interest. On the other hand, available data regarding the prevalence of cardiac rhythm disturbances in IBD, IBS and motility disorders is limited. What is more, pharmacotherapy of the mentioned diseases includes drugs with possible arrhythmogenic potential. In this review we present current experiences and observations concerning gastrointestinal disorders and cardiac rhythm disturbances.

Keywords: Autonomic nervous system, cardiac arrhtytmia, inflammatory bowel disease, irritable bowel syndrome, proarrhythmic drugs.

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Article Details

Year: 2015
Page: [189 - 193]
Pages: 5
DOI: 10.2174/1389450116666150304104453
Price: $65

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PDF: 57