Infectious Pathogens in Acute Atherosclerosis
Pp. 141-151 (11)
Coronary artery disease is the cause of 20% of deaths worldwide, increasing
up to 50% in developed countries. Atherosclerosis is a multifactorial disease that is
strongly affected by inborn and acquired risk factors. It has predisposing factors such as
hypercholesterolemia, hypertension, diabetes mellitus or smoking. The contribution of
infection to atherosclerosis is still a challenge. Infectious agents can aggrevate plaque
rupture, and cause acute myocardial infarction and death. Atherosclerosis is a chronic
inflammatory process. Various bacterial and viral pathogens have been considered as a
cause for inflammation of the vascular wall which leads to atherosclerosis. C.
pneumoniae, H. pylori, influenza A virus, Hepatitis C virus, Cytomegalovirus, and
human immunodeficiency virus (HIV) are related to atherosclerosis. This chapter is
about the potential role of these infectious pathogens in acute atherosclerosis.
Coronary artery disease, acute mycocardial infarction,
atherosclerosis, bacterial pathogens, C. pneumoniae, coagulation,
Cytomegalovirus, endothelial cell, foam cell, gp120, H. pylori, Hepatitis C virus,
HIV, infectious pathogens, inflammation, influenza A virus, macrophage, plaque
rupture, proinflammatory cytokines, viral agents
Izmir University School of Medicine, Medicalpark Hospital, Department of Medical Microbiology, Yeni Girne Boulevard, No:1825, Karsiyaka, Izmir, Turkey.