Pp. 67-77 (11)
Melda Comert, Guray Saydam and Fahri Sahin
Venous thromboembolism (VTE) is a common and preventable disorder
which mostly manifests as deep-vein thrombosis of the legs. The incidence of VTE is 1
to 2 cases per 1000 persons in developed countries. After the first episode of VTE risk
of recurrence increases in these patients, the cumulative rate of recurrence is about 25%
and 30% at 5 years and 10 years respectively. Independent predictors of late recurrence
include increasing patient age and body mass index, leg paresis, active cancer and other
persistent VTE risk factors such as idiopathic VTE, antiphospholipid antibody
syndrome, antithrombin, protein C or protein S deficiency, hyperhomocysteinemia and
a persistently increased plasma fibrin D-dimer. The most important point during
evaluation of VTE is not to forget that it is a multi-factorial status and can be caused by
interaction between the systems which should be investigated carefully.
Acquired hypercoagulability, Activated Protein C Resistance,
Antiphospholipid Syndrome, anti-thrombin, Clotting, Coagulation, D-dimer,
Dysfibrinogenemia, Fibrin, Hyperhomocysteinemia, Inherited hypercoagulability,
Platelets, protein C, protein S, Prothrombin gene mutation, recurrence, risk
factors, Thrombin, thromboembolism, Thrombophila, thrombosis.
Ege University Hospital, Department of Hematology, 35100 Bornova, Izmir, Turkey.