The present work is an agreement with simple and efficient method of improving
the therapeutic efficacy of ibuprofen by masking its acidic moiety. It aims to reduce gastrointestinal
side effects by controlling the rate, duration and site of release. This is achieved
by synthesis and evaluation of polymeric prodrug of ibuprofen with natural polymer sodium
alginate. The synthesis was supported by N-protected serine as spacer due to chemical incompatibility
of drug and polymer. Synthesized prodrug was characterized for confirmation of said structures.
The in-vitro dissolution profile of ibuprofen-alginate prodrug showed that the release of the drug is significantly
higher in case of pH 7.2 buffer as compared to ibuprofen, which might be due to ester group adjacent
to drug get hydrolyzed. The hydrolysis was found to be with faster rate in alkaline media than that of in acidic
Keywords: Ibuprofen, polymeric prodrug, sodium alginate, serine, dissolution, hydrolysis.
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