Nanofibers has gained significant prominence in recent years due to its wide applications in medicinal
pharmacy, textile, tissue engineering and in various drug delivery system. In oral drug delivery system (DDS),
nanofibers can be delivered as Nanofiber scaffolds, electrosponge nanofibers as oral fast delivery system, multilayered
nanofiber loaded mashes, surface modified cross-linked electrospun nanofibers. Nanofibers are of 50-
1000nm size fibres having large surface area, high porosity, small pore size, low density. Various approaches for
formulation of nanofibers are molecular assembly, thermally induced phase separation, electrospining. Most commonly
used by using electrospining polymer nanofibres with different range can be produced collective usage of
electro spinning with pharmaceutical polymers offers novel tactics for developing drug delivery system (DDS).
Different polymers used in preparation of nanofibers include biodegradable hydrophilic polymers, hydrophobic
polymers and amphiphilic polymers. Electrospun nanofibers are often used to load insoluble drugs for enhancing their dissolution properties
due to their high surface area per unit mass. Besides the water insoluble drugs freely water soluble sodium can also spun into the fibers.
The most commonly polymers used for nanofibers are gelatin, dextran, nylon, polystyrene, polyacrylonitrile, polycarbonate, polyimides,
poly vinyl alchol, polybenzimidazole.
Delivery systems reviewed rely on temporal control, changes in pH along the GIT, the action of local enzymes to trigger drug release,
and changes in intraluminal pressure. Dissolution of enteric polymer coatings due to a change in local pH and reduction of azo-bonds to
release an active agent are both used in commercially marketed products. In vitro and in vivo studies have demonstrated that the release
rates of drugs from these nanofiber formulations are enhanced compared to those from original drug substance. This review is focused on
the different type of polymers used, different used in the preparation of nanofibers, cytotoxicity studies and application of nanofiber by
using oral drug delivery.