Title:Effect of Solvents, Drug/Polymer Ratio and Surfactant Concentration on In Vitro Characteristic of Repaglinide Loaded Poly (Meth) Acrylate Nanoparticles
VOLUME: 6 ISSUE: 4
Author(s):A. Lokhande, S. Mishra, R. Kulkarni and J. Naik
Affiliation:Department of Pharmaceutical Technology, University Institute of Chemical Technology, North Maharashtra University, Umavi Nagar, Post Box No. 80, Jalgaon-425 001, Maharashtra, India.
Keywords:Drug release study, eudragit RL, eudragit RS, modified emulsification, stability study.
Abstract:In the present work Repaglinide loaded ammonio methacrylate copolymer nanoparticles were developed
by modified solvent emulsion technique using high pressure homogenizer. An effect of numerous organic
solvents, surfactant concentration, drug-polymer ratios and combination of polymers on encapsulation
efficiency as well as drug release profile were studied. Sustained released nanoparticles were obtained in the
size of less than 400 nm. FE-SEM showed smooth and rigid surface of Eudragit RS nanoparticle’s while porous
surface nature was observed in Eudragit RL nanoparticles. No drug-polymer interaction was found. X-RD revealed
that the crystallinity of repaglinide was decreased when processed with Eudragit polymers. Eudragit RSPO retained drug
for more time than other copolymers. Most of the formulations followed zero order kinetics. Prepared nanoparticles can
be used for the treatment of type 2 diabetes mellitus by minimizing dose rate, reducing adverse effects
and enhancing patient fulfillment.
