Human serum albumin (HSA), a major transport protein component in blood plasma,
has been reported recently to play many important roles in pharmacotherapeutics development.
Owing to its promising intrinsic binding capability of drug molecules, HSA offers favorable
characteristics and can be directly used as its monomeric formula or can be fabricated into
protein based nanoparticle platforms to realize the effective delivery of therapeutic molecules
into targeted diseases areas. In addition, HSA can also serve as a protein stabilizer or
environment-responsive moieties to hybridize with the functional materials including polymers
or inorganic nanoparticles through the covalent reactions or electrostatic interactions, and can
thus greatly alter the relevant biological distribution and pharmacokinetic behavior to improve
their therapeutic efficacy. By right, extensive studies have been conducted to develop HSA-conjugated pharmacotherapeutic agents toward
effective in vitro and in vivo diseases diagnosis and treatment. The current review gives an in-detail account of the latest progresses
of HSA-based carriers as functional protein materials, mainly with respect to its conjugation types, formulation aspects, and importantly
their promising applications towards enhanced drug delivery and medical diagnosis.
Keywords: Human serum albumin, drug delivery, nanoparticle, self-assembly, pharmacotherapeutic agents, covalent conjugation,
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