Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials

Author(s): Marlein Miranda Cona, Raymond Oyen, Yicheng Ni

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 15 , 2015

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Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.

Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.

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Article Details

Year: 2015
Published on: 03 May, 2015
Page: [1829 - 1849]
Pages: 21
DOI: 10.2174/0929867322666150227153550
Price: $65

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PDF: 29