Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell
membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating
process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications
in translational medicine. This article reviews the current concept of necrosis including definition,
etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting
agents and their potential applications in preclinical and clinical settings are also elaborated and
Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.
Rights & PermissionsPrintExport