Abstract
Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.
Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.
Current Medicinal Chemistry
Title:Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials
Volume: 22 Issue: 15
Author(s): Marlein Miranda Cona, Raymond Oyen and Yicheng Ni
Affiliation:
Keywords: Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.
Abstract: Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.
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Cite this article as:
Cona Miranda Marlein, Oyen Raymond and Ni Yicheng, Necrosis Avidity of Organic Compounds: A Natural Phenomenon with Exploitable Theragnostic Potentials, Current Medicinal Chemistry 2015; 22 (15) . https://dx.doi.org/10.2174/0929867322666150227153550
DOI https://dx.doi.org/10.2174/0929867322666150227153550 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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