Nowadays, scientists need to work with non-contaminating technologies. Some approaches include
the use of multicomponent reactions (MCRs), and solid and reusable catalysts. Through MCRs it is possible to
work without isolating intermediate products, so the use of auxiliary solvents is minimized.
Furthermore, catalysis by heteropolycompounds is a field of increasing importance worldwide. Heteropolycompounds
are effective, reusable and stable solid catalysts that have intrinsic multifunctionality: they can be
designed in order to enhance their redox or superacidic properties by varying the atoms in their formula.
The present review presents recent advances in the synthesis of organic compounds through multicomponent reactions by
using heteropolycompounds as catalysts. Some of these compounds are: dihydropyrimidinones, quinazolinones, naphthol
derivatives, pyridines, xanthenones, azabicyclo[2.2.2]octan-5-ones, dispiroheterocycles, imidazoles, spirofused heterocycles,