Title:Downstream Processing of Bioactive Compounds from Milk and Whey
VOLUME: 2 ISSUE: 1
Author(s):Rupesh S. Chavan, Prabhat K. Nema and Vijendra Mishra
Affiliation:National Institute of Food Technology Entrepreneurship and Management, Kundli, India, Plot No 97, Sector-56, HSIIDC Industrial Estate, Kundli-131208, India.
Keywords:Bioactive peptides, ultrafiltration (UF), chromatography, ion-exchange chromatography, size exclusion.
Abstract:Bioactive peptides are specific protein fragments that have a positive impact on functions
and conditions and may ultimately influence health. Milk protein derived active biological constituents,
bioactive peptides, has received much attention for the biological significances. Milk peptides
have shown to possess multiple physiological and physicochemical properties and are therefore regarded
as very important constituents for incorporation in functional and novel foods, dietary supplements
and even pharmaceuticals with the purpose of targeting specific diseases. The current review
will be focusing on the different processes used for fractionation and purification of the bioactive peptides
derived from milk and milk products. At lab-scale, techniques usually followed to concentrate/purify bioactive peptides
are Ultrafiltration membranes, Mass exclusion chromatography, Ion-exchange chromatography, Affinity chromatography
and High-performance liquid chromatography and can be used in different combinations at the industrial scale.
