Bioseparation and downstream processing occupy a complex and important position in biotechnology
and biochemical engineering. Purification and concentration of biological materials requires
new approaches that are gentle enough to protect the biological activity. Osmotic membrane distillation
(OMD) is an interesting alternative for the concentration of thermoliable compounds at ambient
temperature and atmospheric pressure without product deterioration. The main advantage of OMD
process is maximum achievable concentration and can be easily integrated with other separation and
purification processes. This review describes the operational principle, theoretical aspects and recent
applications of osmotic membrane distillation process in biotechnology and allied fields.
Keywords: Osmotic membrane distillation, concentration, biomolecules, downstream process, integrated membrane processes.
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