Ultrasonic Assisted Synthesis of Chromenes Catalyzed by Sodium Carbonate in Aqueous Media

Author(s): Maryam Sabbaghan, Pegah Sofalgar

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 18 , Issue 9 , 2015

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Abstract:

A simple, efficient, and environmentally benign procedure for the synthesis of 2-amino-4Hchromene ring has been achieved by the three-component reaction of an aromatic aldehyde, malononitrile and diverse enolizable C-H activated compound under ultrasound irradiation using sodium carbonate as a catalyst in aqueous media. Sodium carbonate as a natural salt, being available as an inexpensive catalyst combined with ultrasound method promoted this protocol in comparison to other methods and catalysts.

Keywords: Coumarin, dimedone, green synthesis, naphthol, sodium carbonate.

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Article Details

VOLUME: 18
ISSUE: 9
Year: 2015
Page: [901 - 910]
Pages: 10
DOI: 10.2174/1386207318666150224112853
Price: $65

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