Voltammetric and Impidimetric Detection of Anticancer Drug Mitomycin C and DNA Interaction by Using Carbon Nanotubes Modified Electrodes

Author(s): Ece Eksin, Hakan Karadeniz, Arzum Erdem

Journal Name: Current Bionanotechnology (Discontinued)

Volume 1 , Issue 1 , 2015

Graphical Abstract:


The interaction of Mitomycin C with dsDNA was performed with differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) by using carbon nanotubes modified single-use pencil graphite electrode (CNTs-PGE) and bare PGE. The passive adsorption process was used to modify the electrode surface by CNTs and then dsDNA was immobilized onto the modified PGEs by a strong chemical interaction between the amine groups of dsDNA and the carboxyl groups of CNTs. The performance of CNT-PGEs was studied by examining the optimum analytical conditions; MC concentration, interaction time, etc. with voltammetric methods and then impedance method was performed to characterize the modification of CNTs onto the electrode surface.

Keywords: Biosensor, carbon nanotubes, differantial pulse voltammetry, drug-DNA interaction, electrochemical impedance spectroscopy, mitomycin C.

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Article Details

Year: 2015
Published on: 18 February, 2015
Page: [32 - 36]
Pages: 5
DOI: 10.2174/2213529401666150218194827

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PDF: 35