Title:Lipid based Nanocapsules: A Multitude of Biomedical Applications
VOLUME: 16 ISSUE: 4
Author(s):Maha Nasr and Sameh Abdel-Hamid
Affiliation:Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy- Monazamet El Wehda El Afrikia St., El Abbassia, Cairo, Egypt.
Keywords:Drug targeting, interfacial deposition, nanocapsules, phase inversion temperature method, solvent displacement,
surface functionalization.
Abstract:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery
platform in nanometer range with narrow size distribution. They are highly stable in comparison to
other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being
delivered within. The current review sheds the light on the methods of preparation of lipid nanocapsules,
which are simple and easily scalable, in addition to providing examples of post insertion of some
compounds for prolonging vascular circulation, protection, and targeting several diseases. In addition, the review discusses
the vast in vitro and in vivo applications of lipid nanocapsules when administered via different routes such as oral,
parenteral and transdermal routes. Promising use of nanocapsules in treatment of cancer, Alzheimer’s disease, dermatological
conditions and other miscellaneous applications are highlighted.
