Title:Structure, DNA Binding and Cytotoxicity Studies of [Cu(D-glu)(phen)(H2O)]•NO3•2H2O
VOLUME: 12 ISSUE: 8
Author(s):Ling Liu, Jie Mou, Youguang Zheng, Tonghui Huang, Shuaishuai Wang and Yi Liu
Affiliation:Key Laboratory of Brain Diseases Bioimformation (Xuzhou Medical College), Xuzhou 221004, China.
Keywords:[Cu(D-glu)(phen)(H2O)] • NO3 • 2H2O, crystal structure, fluorescence studies, cytotoxic studies.
Abstract:A new complex [Cu(D-glu)(phen)(H2O)]·NO3·2H2O 1 (D-glu = D-glutamic acid, phen =
1,10-phenanthroline) was synthesized and identified by IR spectroscopy and single-crystal X-ray diffraction.
Fluorescence studies showed that 1 exhibited stronger intercalative interaction to CT-DNA as compared
to known complex [Cu(L-glu)(phen)(H2O)]·NO3·2H2O 2. Both complexes inhibited the growth of
MCF-7 cells with the IC50 values of 0.141 μmol·L-1 and 0.126 μmol·L-1 for complex 1 and 2, respectively.
The complexes were 20 times more active than the amino acid - free complex
[Cu(phen)(H2O)2(NO33)] · NO3 3.
