Lysosomal Enzymes and their Receptors in Invertebrates: An Evolutionary Perspective

Author(s): Nadimpalli Siva Kumar, Poorna M. Bhamidimarri

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 1 , 2015

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Graphical Abstract:


Lysosomal biogenesis is an important process in eukaryotic cells to maintain cellular homeostasis. The key components that are involved in the biogenesis such as the lysosomal enzymes, their modifications and the mannose 6-phosphate receptors have been well studied and their evolutionary conservation across mammalian and non-mammalian vertebrates is clearly established. Invertebrate lysosomal biogenesis pathway on the other hand is not well studied. Although, details on mannose 6-phosphate receptors and enzymes involved in lysosomal enzyme modifications were reported earlier, a clear cut pathway has not been established. Recent research on the invertebrate species involving biogenesis of lysosomal enzymes suggests a possible conserved pathway in invertebrates. This review presents certain observations based on these processes that include biochemical, immunological and functional studies. Major conclusions include conservation of MPR-dependent pathway in higher invertebrates and recent evidence suggests that MPR-independent pathway might have been more prominent among lower invertebrates. The possible components of MPR-independent pathway that may play a role in lysosomal enzyme targeting are also discussed here.

Keywords: Biogenesis, invertebrates, lectin, lysosomal enzymes, mannose 6-phosphate receptors, sortilin.

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Article Details

Year: 2015
Page: [49 - 65]
Pages: 17
DOI: 10.2174/1389203716666150213161311

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PDF: 41