The rationale behind present work was to formulate a novel cream containing microsponges
of miconazole nitrate to provide prolonged release. By means of quasi-emulsion solvent diffusion
method using Eudragit RS-100 with different drug-polymer ratios microsponges were prepared. In the
direction of optimizing microsponge formulation, diverse factors that affect microparticles physical
properties were also investigated. Microsponges were characterized by SEM, DSC, FT-IR and particle
size analysis, and also evaluated for morphology, drug loading and in vitro drug release. The drug
polymer ratio reflected notable effect on drug content, encapsulation efficiency and particle size. It has been found that
there was no chemical interaction between drug and polymers used as revealed by FT-IR and DSC spectra. SEM micrographs
exposed that microsponges were spherical, with porous surface and have had 26.23 μm mean particle size. The microsponges
were then incorporated in cream; which showed viscous modulus along with pseudoplastic behavior. In vitro
drug release results depicted that microsponge with drug-polymer ratio of 1:2 was more efficient to give extended drug release
of 78.28% at the end of 8 h; while conventional formulations get exhausted incredibly earlier by releasing 83.09%
drug at the end of 4 h only. Thus the formulated cream containing microsponges of miconazole nitrate would be a promising
alternative as compared to conventional therapy for secure and efficient treatment of acne and other topical infections.
Keywords: Acne, controlled release, drug delivery, miconazole nitrate, microsponges.
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