Abstract
Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport vector tools for the delivery of a large variety of cargoes through the cell membrane, as well as other physiological membranes. And since they’re relatively cell-, receptor- and energy-independent, CPPs have unique advantages in facilitating drugs entry into cells. This paper briefly reviews the discovery, mechanism and classification of CPPs, and especially focuses on the specific limitations of CPPs and their potential applications for tumor-targeted delivery of biologically active molecules, imaging agents and carriers.
Keywords: Cell penetrating peptides, tumor, targeting.
Current Cancer Drug Targets
Title:Cell-penetrating Peptides for Cancer-targeting Therapy and Imaging
Volume: 15 Issue: 4
Author(s): Weiqin Wang, Sarra Abbad, Zhenhai Zhang, Shu Wang, Jianping Zhou and Huixia Lv
Affiliation:
Keywords: Cell penetrating peptides, tumor, targeting.
Abstract: Cell-penetrating peptides (CPPs) have been previously shown to be powerful transport vector tools for the delivery of a large variety of cargoes through the cell membrane, as well as other physiological membranes. And since they’re relatively cell-, receptor- and energy-independent, CPPs have unique advantages in facilitating drugs entry into cells. This paper briefly reviews the discovery, mechanism and classification of CPPs, and especially focuses on the specific limitations of CPPs and their potential applications for tumor-targeted delivery of biologically active molecules, imaging agents and carriers.
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Cite this article as:
Wang Weiqin, Abbad Sarra, Zhang Zhenhai, Wang Shu, Zhou Jianping and Lv Huixia, Cell-penetrating Peptides for Cancer-targeting Therapy and Imaging, Current Cancer Drug Targets 2015; 15 (4) . https://dx.doi.org/10.2174/1568009615666150211104524
DOI https://dx.doi.org/10.2174/1568009615666150211104524 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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