Target Based Drug Design - A Reality in Virtual Sphere

Author(s): Saroj Verma, Yenamandra S. Prabhakar

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 13 , 2015

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Abstract:

The target based drug design approaches are a series of computational procedures, including visualization tools, to support the decision systems of drug design/discovery process. In the essence of biological targets shaping the potential lead/drug molecules, this review presents a comprehensive position of different components of target based drug design which include target identification, protein modeling, molecular dynamics simulations, binding/catalytic sites identification, docking, virtual screening, fragment based strategies, substructure treatment of targets in tackling drug resistance, in silico ADMET, structural vaccinology, etc along with the key issues involved therein and some well investigated case studies. The concepts and working of these procedures are critically discussed to arouse interest and to advance the drug research.

Keywords: Drug resistance, homology modeling, molecular dynamics simulations, structure based drug design, structural vaccinology, target based drug design, target site identification, virtual screening.

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Article Details

VOLUME: 22
ISSUE: 13
Year: 2015
Page: [1603 - 1630]
Pages: 28
DOI: 10.2174/0929867322666150209151209
Price: $65

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